Test on In Vitro Maturation: Biphasic Protocols

Question 1: In the Vuong et al., HR 2020 randomized controlled trial, the Biphasic IVM group had similar miscarriage rates compared to the stimulated IVF group.

A. Ano

B. Ne

Explanation: The study materials for Vuong et al., HR 2020 state that there were 'Similar miscarriage rates, obstetric and perinatal outcomes between IVM and OS-IVF'.

Question 2: According to the Vuong et al., HR 2020 study, how did In-vitro Maturation (IVM) compare to conventional IVF regarding perinatal outcomes?

A. IVM resulted in significantly worse perinatal outcomes than conventional IVF.

B. IVM resulted in significantly better perinatal outcomes than conventional IVF.

C. IVM showed similar perinatal outcomes to conventional IVF.

D. The study did not report on perinatal outcomes for either group.

Explanation: The Vuong et al., HR 2020 study explicitly states that there were 'Similar miscarriage rates, obstetric and perinatal outcomes between IVM and OS-IVF'.

Question 3: During the IVM step of Biphasic IVM, meiotic reinitiation is induced solely by the addition of Insulin and Estradiol.

A. Ano

B. Ne

Explanation: The study materials indicate that during the IVM step, meiotic reinitiation (or 'Induce Maturation') is achieved through 30 hours of incubation with AREG, Insulin, FSH, and Estradiol. Therefore, it is not solely induced by Insulin and Estradiol.

Question 4: The clinical pregnancy rate for Biphasic IVM Version 3.0 was below 50%.

A. Ano

B. Ne

Explanation: According to the 'Gonadotropin-Free / PCOS women: Fresh (3.0) vs Freeze-all (2.0)' table, the clinical pregnancy rate for Biphasic IVM Version 3.0 ('Fresh ET first') was 60%, which is not below 50%.

Question 5: Based on the study materials, which of the following describes the study cohort for Biphasic IVM in aged PCOS women?

A. A group of 74 women with a mean age of 37.2 years, tracking outcomes from oocyte retrieval to cumulative live birth rate.

B. A pilot study of 20 non-PCOS patients with good ovarian reserve.

C. Women aged 36-44 years who are candidates for elective egg freezing.

D. A small cohort of women with Gonadotropin Resistant Ovary Syndrome.

Explanation: The study materials state under 'Biphasic IVM for aged PCOS women (36-44yr)' that there was a 'Study cohort of 74 women (mean age 37.2) tracking progression from oocyte retrieval to cumulative live birth rate'.