Flashcards on Fresh and Frozen Embryo Transfer Outcomes
Fresh vs. Frozen Embryo Transfer Outcomes: An SEO Guide
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Embryo transfer strategies
10 cards
Card 1
Question: What are the two main embryo transfer strategies compared in IVF cycles?
Answer: Fresh embryo transfer versus a 'freeze-all' strategy followed by frozen embryo transfer (FET).
Card 2
Question: Historically, how were embryos managed before routine freezing?
Answer: No embryo freezing; multiple embryos were transferred after oocyte pickup and 'excess' embryos discarded.
Card 3
Question: What is the main clinical reason to consider a 'freeze-all' strategy?
Answer: To avoid endometrial effects from high-dose gonadotrophins and reduce risk of OHSS in high-risk women.
Card 4
Question: List two potential advantages and two disadvantages of a 'freeze-all' approach.
Answer: Advantages: may avoid OHSS and possibly improve success in some groups. Disadvantages: longer time to pregnancy, higher cost and more procedural steps
Card 5
Question: In which patient group did randomized trials show a clear advantage of freeze-all for live birth rate?
Answer: Women with PCOS showed higher live birth rates with freeze-all then FET compared with fresh transfer in one RCT (2016).
Card 6
Question: In ovulatory (non-PCOS) women, how do freeze-all and fresh strategies compare for live birth rates?
Answer: Trials showed similar live birth rates between freeze-all (FET) and fresh transfer in ovulatory women.
Card 7
Question: How did birthweights compare between frozen and fresh transfers in several trials?
Answer: Babies after frozen transfers tended to be heavier than after fresh transfers (examples: 3.5 vs 3.1 kg in pooled/mentioned data).
Card 8
Question: Which strategy is recommended for women at high risk of OHSS?
Answer: Freeze-all (followed by FET) is suitable for women at high risk of OHSS.
Card 9
Question: What trade-off is noted with a freeze-all strategy besides cost and delay?
Answer: Possible increased risk of pre-eclampsia is suggested as an uncertain/possible downside in some studies.
Card 10
Question: What practical outcome differences were reported regarding multiple pregnancy rates between fresh and frozen transfers in trials that used mostly Day
Answer: Multiple pregnancy rates were similar or slightly higher in frozen groups in some trials (examples: frozen 15.7% vs fresh 14.2% in one study), reflect