Flashcards on Herpes Simplex Virus: Pathogenesis and Therapies
Herpes Simplex Virus: Pathogenesis & Therapies Guide
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HSV immunology
72 cards
Card 1
Question: Which immune cells are directly activated by HSV antigens via TLR2, facilitating their presentation to CD4 T lymphocytes?
Answer: Natural killer (NK) cells are directly activated by HSV antigens via TLR2, facilitating their presentation to CD4 T lymphocytes.
Card 2
Question: What effect does infection of mature dendritic cells with HSV-1 have on lymphoid chemokine-mediated migration?
Answer: Infection of mature dendritic cells with HSV-1 dramatically reduces lymphoid chemokine-mediated migration.
Card 3
Question: How does deletion of the US6 gene in HSV-2 affect dendritic cell function and T cell activation?
Answer: US6 gene deletion in HSV-2 enhances dendritic cell function and T cell activation.
Card 4
Question: Why is inhibition of MHC class I important for HSV virulence in mice?
Answer: Inhibition of MHC class I is a virulence factor in HSV infection of mice, implying it helps the virus evade immune detection.
Card 5
Question: Which HSV glycoprotein acts as a receptor for complement component C3b on infected cells?
Answer: Glycoprotein C (gC) of HSV-1 acts as a receptor for the C3b complement component on infected cells.
Card 6
Question: What is the role of HSV glycoproteins gC-1 and gC-2 in complement interaction?
Answer: gC-1 and gC-2 bind to the third component of complement (C3) and provide protection against complement-mediated neutralization of viral infectivity.
Card 7
Question: How does HSV-1 evade antibody and complement effects in vivo according to the cited studies?
Answer: HSV-1 evades effects of antibody and complement in vivo through functions of glycoprotein C and other immune-modulating mechanisms described in the re
Card 8
Question: What ability of HSV glycoprotein C prevents complement-mediated neutralization induced by natural IgM?
Answer: HSV glycoprotein C (from types 1 and 2) prevents complement-mediated neutralization induced by natural IgM antibody.
Card 9
Question: How does the HSV-1 IgG Fc receptor affect antibody functions?
Answer: The HSV-1 IgG Fc receptor blocks antibody-mediated complement activation and antibody-dependent cellular cytotoxicity (ADCC).
Card 10
Question: What immunological responses are nucleoside-modified mRNA vaccines reported to induce that are relevant to HSV immunology?
Answer: Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses, which are relevant for HSV immunology.