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Intracytoplasmic Sperm Injection (ICSI) Overview

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Intracytoplasmic sperm injection (ICSI) consistently leads to a higher euploidy rate in embryos compared to conventional insemination in cases of nonmale factor infertility.

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In trials comparing ICSI and conventional IVF, how did livebirth rates generally compare between groups (examples from Dang 2021 and Wang 2024)?

Dang 2021: ICSI 35% vs IVF 31% livebirths. Wang 2024: ICSI 33.8% vs IVF 36.6% (no statistically significant difference; adjusted RR ~0.92, p=0.16).

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